Can methotrexate cause weight loss?

Question

My sister started methotrexate treatment for her autoimmune condition a few months ago, and she's lost a lot of weight very rapidly. We're concerned if this medication can cause such significant weight loss.

Ananya Joshi · Accepted Answer

Yes, methotrexate can cause weight loss, mostly because it can cause nausea and loss of appetite. Focus on eating small, nutrient-dense vegetarian meals like dal khichdi and sprouts, and try not to force large meals when you feel sick.

Vikram Sen · Answer

It can indeed cause weight loss due to decreased appetite or stomach upset. Try to take it easy, eat whatever mild food you can tolerate, and definitely let your doctor know.

Sneha Roy · Answer

I totally get it, losing weight suddenly when you are already dealing with an illness is so stressful. Methotrexate can mess with your stomach and make you lose interest in food. Please speak to your doctor if the weight loss is rapid.

Savita Roy · Answer

I lost quite a bit of weight when I first started methotrexate because food tasted metallic and made me sick. Slowly, my body adjusted and my weight stabilized. Keep your strength up with small, regular meals.

Rohan Das · Answer

Haha, I guess that is one extreme way to lose weight, but definitely not the fun kind! The nausea from methotrexate can really kill your appetite. Don't worry too much, just eat small meals and it should settle down.

Meera Deshmukh · Answer

Many patients on methotrexate report weight loss due to side effects like nausea or mouth ulcers. Taking your prescribed folic acid on non-methotrexate days really helps reduce these digestive issues. Keep your doctor informed about any changes.

Can methotrexate cause weight loss?

6 answers

Consult a dietary specialist

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