Does methotrexate cause weight gain?

It doesn't directly cause fat gain like steroids do, but fatigue can lower your daily calorie burn. I tracked my steps and kept an eye on my daily activity using my fitness band, which helped me manage my weight while on this medication.

Sometimes the body holds onto water when we are on heavy treatments. Gentle pranayama and light walking really helped me keep my metabolism stable and reduced the heavy feeling in my body during my treatment days.

Direct weight gain isn't a very common side effect of methotrexate itself, unlike prednisone. However, if you are feeling bloated or noticed sudden swelling, you should let your clinic know so they can check your kidney and liver functions.

Look, don't blame the medicine completely for weight gain. Often we eat more comfort food because we feel low or tired on methotrexate days. Keep your diet simple and ghar ka khana, and the weight won't go up.