Is ibuprofen metabolized in the kidneys or liver?
My father has some health concerns with both his kidneys and liver. He sometimes takes ibuprofen for headaches. I'm worried and want to know, is ibuprofen metabolized in the kidneys or the liver?
5 answers
6 months ago
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Honestly, I haven't slept in 24 hours so my own brain feels un-metabolized, but I recall my doctor telling me it is metabolized by the liver first, though it's the kidneys that do the work to filter and excrete it. Don't stress them both too much!
8 months ago
It's a team effort! The liver metabolizes it, and the kidneys flush it out of your system. Just drink lots of water so your kidneys don't write an angry letter to you, haha!
8 months ago
According to my physician, ibuprofen is metabolized primarily in the liver through oxidation, but the active compounds are filtered and excreted mainly by the kidneys. That is why people with kidney issues are warned to avoid it.
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yrs exp
7 months ago
It is metabolized in the liver but excreted through the kidneys. Because of this, long-term use can strain your renal system. Always take it with plenty of fluids and never beyond the recommended dose.
8 months ago
I am not a doctor, but when I had to take it for my knee pain, my doctor mentioned it is processed by both organs—metabolized by the liver and cleared by the kidneys. I just followed his exact dosage to be safe.