Amol Kulkarni Amol Kulkarni Asked 4 months ago

Can methotrexate cause cancer?

My rheumatologist has prescribed methotrexate for my severe arthritis. I'm a bit concerned because I've heard conflicting things about it and cancer risk. Can methotrexate actually cause cancer?

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7 answers

Sandeep Rao Sandeep Rao Joined Feb 2026 4 months ago
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While methotrexate is an immunosuppressant used to treat autoimmune conditions, there is a very small, rare risk of lymphoma or skin cancers with long-term use. Please consult your rheumatologist regularly to monitor your blood work and skin for safety.

Sanjay Bhatia Sanjay Bhatia Joined May 2026 4 months ago

At my age, reading the side effects of these medicines makes me feel like I am reading a horror novel! Yes, there is a tiny risk mentioned in the leaflets, but my doctor told me it's very rare. I’d rather face the tiny risk than live with crippled joints.

Shalini Nair Shalini Nair Joined Apr 2026 4 months ago

I was on methotrexate for my rheumatoid arthritis for two years and had the same fear. My doctor kept a very close eye on my dosage and regular lab tests. Trust your doctor, the benefits for severe joint damage often outweigh these rare risks.

Sherin Thomas Sherin Thomas Joined Apr 2026 4 months ago

The cancer risk with low-dose weekly methotrexate used for autoimmune conditions is actually very minimal. We monitor patients with regular blood counts and liver tests. Just stick to your prescribed dose and folic acid, and you will be fine.

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Consult a radiation oncologist

Savita Roy Savita Roy Joined Jul 2026 4 months ago

I have been taking low-dose methotrexate for fifteen years for my psoriasis. I have regular checkups and my health has been perfectly fine. Do not let these rare side effects scare you away from a medicine that can give you your life back.

Gurbaksh Singh Gurbaksh Singh Joined Feb 2026 4 months ago

Beta, strong medicines like this should be taken strictly as the doctor says. To keep the body clean, drink lots of water and eat fresh home-cooked food. Do not stop the treatment on your own due to fear.

Rohan Sen Rohan Sen Joined May 2026 4 months ago

I was researching this because my mother was prescribed methotrexate. From what I read, the risk of cancer like lymphoma is extremely low and mostly applies to high doses used in cancer therapy, not the low weekly doses used for arthritis.

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