Rina Kapoor Rina Kapoor Asked 7 months ago

Can i take tylenol with excedrin migraine?

I get terrible migraines and usually take Excedrin Migraine for relief. Today, the pain is extra severe, and I'm wondering if I can take a Tylenol along with it to make it better. Is mixing them safe to do?

6

6 answers

Varun Malhotra Varun Malhotra Joined May 2026 5 months ago
Most liked

Bro, definitely do not mix them. I once made the mistake of taking both for a bad headache, and then realized both have paracetamol in them. It can really overload your liver, so just stick to one and ask your doctor.

Sanjay Gupta Sanjay Gupta Joined Jan 2026 7 months ago

At our age, our livers have enough work to do without us double-dosing on painkillers! Since both these medicines have acetaminophen, taking them together is a bad idea. Better to call your doctor if the pain isn't going away.

Riya Sen Riya Sen Joined Mar 2026 7 months ago

Omg, dont do that! Both have the same active ingredient, so mixing them is basically an accidental overdose. Try resting in a dark room and definitely text your doctor if u need stronger relief.

Powered by

Consult a neurologist

Neha Nair Neha Nair Joined Apr 2026 7 months ago

I literally just asked my doctor about this during my migraine attack last week. He strictly warned me that Excedrin already contains a high amount of acetaminophen, which is the same as Tylenol. Taking them together is a double dose and unsafe.

Druti Das Druti Das Joined Mar 2026 7 months ago

Combining Tylenol and Excedrin Migraine is highly discouraged because of the risk of acetaminophen toxicity, which can damage your liver. Please consult a physician or pharmacist to discuss safer alternatives for your headache.

Related reads

All articles
Rajesh Kulkarni Rajesh Kulkarni Joined Apr 2026 7 months ago

Having dealt with chronic migraines for years, I know the desperation to stop the pain. But taking Tylenol on top of Excedrin is a major risk because of the overlapping paracetamol content. If your migraine isn't responding, talk to your doctor about triptans or other targeted therapies.

Evidence-based health, reviewed by clinicians. Free, weekly.